Sericulture generates large volumes of valuable by-products, particularly silkworm pupae, litter, reeling effluents and plant waste, collectively termed seri-waste. These by-products possess immense nutritional, medicinal and industrial potential, making sericulture a sustainable, zero-waste enterprise. Silkworm pupae are rich in high-quality proteins, essential amino acids, vitamins, minerals and bioactive compounds with antioxidant, antimicrobial, anticancer and metabolic health benefits. Their oils contain beneficial unsaturated fatty acids, while larvae and excreta support biogas production, organic farming and compost enrichment. With the rising global demand for eco-friendly food and agricultural resources, the efficient utilisation of seri-waste offers a promising avenue for enhancing food security, environmental sustainability and rural livelihoods.