Squalene is natural potent antioxidant present in vegetable oil, fish liver oil, palm oil, grain amaranth, buckwheat etc. It is mainly used in skin care products due to photoprotective agent and strongly quenches free radicals. Commercially squalene is derived from deodorized distillate from the refining of vegetable oil followed by extraction either by solvent or super critical fluid extraction method. Micronized squalene emulsions are being used as immune adjuvant, treat the COVID 19. Natural source of squalene served the functions of nutraceuticals i.e. prevention and treatment of CVD, improves the immunity, increase the GSH, CAT, SOD hormones to quenches the free radicals in cellular level. Squalene's potential health benefits are attributed to its antioxidant, anti-inflammatory and cardio protective properties, among others. Hence, the consumption of squalene rich foods can boost immunity, improve skin health and also maintain healthy life style.