Nutrient-based biofortification is an emerging concept to enhance the nutritional value of food crops and combat micronutrient malnutrition or ?hidden hunger.? Optimal use of macronutrients and micronutrients increases the efficiency of nutrient uptake, translocation, and accumulation in the edible plant parts like grains, fruits, and tubers. Macronutrients such as nitrogen, phosphorus, and potassium, and micronutrients such as iron, zinc, boron, copper, manganese, and selenium are important for enhancing crop productivity as well as food quality. Practices like soil test-based fertilisation, foliar nutrient spraying, integrated nutrient management, and the use of organic manures and beneficial microbes help increase the availability of nutrients and efficient nutrient use. Nutrient-based biofortification is a cost-effective, farmer-friendly, and environmentally safe approach that can be easily practiced in different agro-climatic zones. Therefore, it provides a long-term solution to enhance food and nutritional security. Eating biofortified crops regularly can help overcome micronutrient deficiencies in the vulnerable sections of society. Extension and policy support can further help in improving the adoption of nutrient-based biofortification practices.