Endosperm balance number is a ratio between maternal and paternal genetic contributions necessary for proper seed development. Deviation from this ratio results in seed abortion, a phenomenon termed the triploid block. This post-zygotic barrier limits polyploid breeding. Genomic imprinting is an epigenetic phenomenon which is related to parent-of-originspecific gene expression. It ensures and maintains the endosperm balance number. Deviation from this ratio is commonly observed in interspecific or interploidy crosses, resulting in abnormal endosperm development leading to triploid block. It often acts as a hybridization barrier in breeding to transfer the useful traits between species with different ploidy level. On the other hand, it contributes to reproductive isolation mechanisms, influencing plant evolution and diversification. The triploid block can be circumvented by different methods like chemical treatment, embryo rescue techniques, hormonal treatments, genetic and epigenetic modifications.