The energy and protein are the major nutrients need to be supplied at sufficient levels for optimum productive and reproductive performances of livestock. Day-to-day increasing prices of energy and protein feed ingredients have been significantly affecting profitability of livestock enterprises for feeding being the major expense. Searching for alternatives is one of the viable options to curtail feeding cost in livestock enterprises. With the growing biofuel industries, their byproducts may be potential alternatives to conventional energy and protein feed ingredients for livestock. Exploiting biofuel co-products based on nutritional and anti-nutritional components and finding out suitable feeding level will help to address feed shortage optimizing livestock productivity and economic sustainability.