The mechanization of agriculture in Odisha has improved productivity but increased safety risks. Tractors, tractor-trailers, and other farm machinery, often operated without proper training or safety measures, are major contributors to accidents, injuries, and fatalities. Common causes include rollovers, overloading, unsafe passenger transport, and collisions on narrow or uneven roads. These incidents result in significant human, social, and economic losses, particularly among small and marginal farmers. Although regulations such as the Odisha Dangerous Machines (Regulation) Rules, 2008, aim to improve safety, enforcement gaps, limited training, and poor infrastructure persist. This study highlights patterns and impacts of machinery-related accidents and recommends preventive strategies, including mandatory inspections, operator training, safety retrofitting, improved rural infrastructure, awareness campaigns, and strengthened emergency response. Implementing these measures can reduce accidents, protect livelihoods, and support sustainable agricultural modernization in Odisha.