Lumpy skin disease (LSD) is a highly infectious and economically devastating viral disease of cattle. It is caused by Lumpy Skin Disease Virus (LSDV) belonging to the genus Capripoxvirus and family Poxviridae. The transmission of the virus occurs mainly through direct contact with infected animals or by insect vectors like Stomoxys, Culicoides, etc. The disease is characterised by firm, well-defined skin nodules ranging from few to multiple, depending on the severity of the case. The deep skin nodules may extend into tissue and muscles, leading to vasculitis, edema, congestion, haemorrhage. It may also cause bronchopneumonia, enlargement of lymph nodes and also affect other internal organs. This disease results in reduced milk yield, abortions, infertility, hide damage, and even death, all of which cause significant economic losses to farmers. Hence, widespread vaccination with indigenous homologous LSD vaccine along with restriction of livestock movement, vector movement and strict biosecurity measures should be followed to reduce the transmission of lumpy skin disease.