The overuse of chemical pesticides has raised significant concerns about environmental health, soil degradation, and food safety. In response, Zero Budget Natural Farming (ZBNF), championed by Subhash Palekar, emphasizes the use of traditional liquid organic manures such as Jeevamrit, Beejamrit, Panchagavya, Sonthastra, Khatti Lassi, and Brahmastra. These formulations, derived from cow-based products and medicinal plant extracts, are rich in beneficial microbes and secondary metabolites with proven antimicrobial properties. This review outlines their preparation, microbial composition, and effectiveness in managing key plant pathogens such as Fusarium spp., Rhizoctonia solani, Colletotrichum spp., and rootknot nematodes. These bio-inputs enhance soil fertility, improve crop resilience, and provide a sustainable alternative to synthetic agrochemicals, aligning traditional practices with modern ecological farming needs.