Potato (Solanum tuberosum L. is a staple crop with a complex tetraploid genome, making conventional breeding for desirable traits challenging. Genome editing using CRISPR-Cas technology has emerged as a powerful tool for precise genome editing in potatoes, enabling targeted modifications for disease resistance, stress tolerance, and quality improvement. CRISPR and its related tools have really zoomed into helping to remove genes that make something vulnerable and to tweak metabolic pathways, and to generally beef up traits important to farming without throwing in DNA from other places. Compared to traditional methods of change, CRISPR and Cas are a lot finer, more efficient and considerably reduce regulatory worries too. This review explores recent advancements in CRISPR-Cas-based genome editing in potatoes, detailing its applications, challenges, and future prospects. Key aspects such as delivery methods, target genes, and regulatory considerations are discussed. While CRISPR-Cas revolutionizes potato improvement, challenges such as off-target effects, low editing efficiency in polyploids, and regulatory frameworks need further refinement. Future innovations will enhance its applicability in sustainable potato breeding.