Antioxidants plays a very important role in poultry feed formula on bird's ecophysiology. Oxidative stress cause biological deterioration, which can impede farm animals' ability of production. Oxidative stress in chicken production can be brought on by a number of things, including illnesses, high metabolic rates, stressful environments and inadequate nutrition. This oxidative stress results in formation of reactive oxygen species (free radicals). These free radicals have negative impact on growth, immune status, elevated lipid rancidity and poor quality of meat. Numerous substances, such as fat and water-soluble molecules, which the body may either naturally produce or augment with food, have antioxidant properties. These antioxidants additive usually utilized in order to increase the stability of feed. Supplementing poultry diets with antioxidants improves bird health by enhancing immune function, reducing inflammation, and protecting tissues from oxidative damage, making natural antioxidants more appealing due to consumer demand. This article delves into the biochemical roles of essential antioxidants in poultry nutrition, their impact on performance, and their potential to enhance the sustainability and welfare of modern poultry production systems.