Aquaculture, as a significant contributor to global food security, faces challenges such as microbial infections, biofouling, and water quality degradation. Understanding microbial communication mechanisms, particularly Quorum Sensing (QS), is crucial for addressing these challenges. QS enables bacteria to coordinate behaviors based on population density, influencing processes like biofilm formation and virulence expression. This article explores the QS mechanism, its importance in microbial communication, and its applications in enhancing aquaculture practices.