Mango (Mangifera indica L.) is a vital fruit crop in Telangana, India, but post-harvest diseases threaten its production, causing significant economic losses. This study examines the prevalence, impact, and management of post-harvest diseases in Telangana's mango production, emphasizing integrated disease management. Recommendations for efficient harvesting, handling, storage, transportation, and marketing are provided to mitigate losses and enhance competitiveness. By integrating cultural, biological, physical, and chemical control methods and fostering collaboration among stakeholders, Telangana can sustainably manage post-harvest diseases, ensuring the long-term success of its mango industry.