Soil, beyond its role in agriculture, holds immense therapeutic potential recognized since ancient times. Historically, civilizations utilized soil-based remedies, such as clay, to heal wounds, treat digestive issues, and detoxify the body. Modern science further uncovers soil?s medicinal properties, including clay minerals for detoxification, soil microbes for antibiotics and bioactive compounds, and humic substances to boost immunity. Emerging applications like soil-based probiotics, clay nanoparticles in drug delivery, and soil-derived cancer treatments demonstrate its diverse benefits. However, challenges persist in standardization, quality control, and regulatory frameworks. With advancements in research and sustainable practices, soil could redefine healthcare by fostering innovative therapies and ecological well-being, emphasizing the profound interconnectedness of humans and nature.